Hydrogen-rich water inhibits glucose and α,β -dicarbonyl compound-induced reactive oxygen species production in the SHR.Cg-Leprcp/NDmcr rat kidney.
Masanori Katakura, Michio Hashimoto, Yoko Tanabe, Osamu Shido · Medical gas research · 2012
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Independent study record
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H2HUBB TAKEAWAY
Cg-Leprcp/NDmcr rats treated with HRW showed a 34% decrease in ROS production. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
In this study, the researchers investigated the effects of HRW on glucose- and α,β-dicarbonyl compound-induced ROS generation in vitro and in vivo.
How Molecular Hydrogen Was Used
Molecular hydrogen was administered as hydrogen-rich water.
What the Researchers Found
SHR.Cg-Leprcp/NDmcr rats treated with HRW showed a 34% decrease in ROS production.
H₂ Mechanisms / Biological Findings
Reported molecular-hydrogen-related mechanisms included hydrogen-rich water (HRW) increases the H₂ level in blood and tissues, thus reducing oxidative stress in animals as well as humans.
Authors’ Conclusion
The authors concluded that these results indicate that HRW inhibits the production of α,β-dicarbonyl compounds and ROS in the kidneys of SHR.Cg-Leprcp/NDmcr rats.