Hydrogen saline prevents selenite-induced cataract in rats.
Chun-xiao Yang, Hong Yan, Tian-bing Ding · Molecular vision · 2013
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Independent study record
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H2HUBB TAKEAWAY
In rats, compared with Group B, the mean activities of the antioxidant enzymes superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glutathione S-transferase, levels of GSH, and total sulfhydryl contents were higher, whereas the level of malondialdehyde was lower following treatment with hydrogen saline. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
The aim of this study was to investigate the potential antioxidative effect and mechanism for the protective effects of hydrogen saline on selenite-induced cataract in rats.
How Molecular Hydrogen Was Used
Group C also received an intraperitoneal injection of H₂ saline (5 ml/kg bodyweight) daily from postnatal day 8 to postnatal day 17.
What the Researchers Found
Compared with Group B, the mean activities of the antioxidant enzymes superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glutathione S-transferase, levels of GSH, and total sulfhydryl contents were higher, whereas the level of malondialdehyde was lower following treatment with hydrogen saline(p<0.05).
H₂ Mechanisms / Biological Findings
The aim of this study was to investigate the potential antioxidative effect and mechanism for the protective effects of hydrogen saline on selenite-induced cataract in rats.
Authors’ Conclusion
The authors concluded that this is an initial report showing that hydrogen saline can prevent selenite-induced cataract in rats.