Hydrogen treatment attenuates ferroptosis and alleviates spinal cord ischemia-reperfusion injury by activating the Nrf2/HO-1 signaling pathway.
Jian Tong, Jie Liu, Zhengming Lv · Molecular biology reports · 2026
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
In Following oxygen-glucose deprivation/reoxygenation (OGD/R), HT22 cells were treated with H₂ to assess its impact on ferroptosis, the administration of H₂ significantly improved hindlimb motor function in SCIRI rats, concurrently reducing cellular ROS, Fe2+, MDA, and ACSL4 levels. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen affected the outcomes measured in Following oxygen-glucose deprivation/reoxygenation (OGD/R), HT22 cells were treated with H₂ to assess its impact on ferroptosis. The administration of H₂ significantly improved hindlimb motor function in SCIRI rats, concurrently reducing cellular ROS, Fe2+, MDA, and ACSL4 levels.
What the Researchers Studied
The researchers studied Following oxygen-glucose deprivation/reoxygenation (OGD/R), HT22 cells were treated with H₂ to assess its impact on ferroptosis. The study used a in vitro cell-culture laboratory experiment.
What Effects Did Molecular Hydrogen Have?
Following oxygen-glucose deprivation/reoxygenation (OGD/R), HT22 cells were treated with H₂ to assess its impact on ferroptosis. The administration of H₂ significantly improved hindlimb motor function in SCIRI rats, concurrently reducing cellular ROS, Fe2+, MDA, and ACSL4 levels. The authors linked these findings to activation of the Nrf2/HO-1 signaling pathway.
Why These Findings Matter
These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
How Strong Is This Evidence?
This is laboratory evidence from a in vitro cell-culture laboratory experiment. It is most informative for the biological mechanisms, cellular responses, or biochemical outcomes directly measured.
Technical Study Details
H2HUBB classifies this publication as laboratory study with laboratory or cellular evidence. The research population or model was Following oxygen-glucose deprivation/reoxygenation (OGD/R), HT22 cells were treated with H₂ to assess its impact on ferroptosis. The study used a in vitro cell-culture laboratory experiment.
Limitations and Safety
No separate limitations or safety findings were identified in the current-study source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.