Consumption of hydrogen-rich water protects against ferric nitrilotriacetate-induced nephrotoxicity and early tumor promotional events in rats.
Fang-Yin Li, Shao-Xing Zhu, Zong-Ping Wang, Hua Wang, Yang Zhao, Gui-Ping Chen · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2013
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
In rats, consumption of hydrogen-rich water decreased the incidence of renal cell carcinoma and suppressed tumor growth in Fe-NTA-treated in rats. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
The study examined rats.
How Molecular Hydrogen Was Used
The aim of this work was to test whether consumption with hydrogen-rich water (HW) alleviated renal injury and inhibited early tumor promotional events in Ferric nitrilotriacetate (Fe-NTA)-treated rats.
What the Researchers Found
Consumption with HW suppressed Fe-NTA-induced inflammation marked by reduced NF-κB, IL-6, and MCP-1 expression and macrophage accumulating in kidneys. Consumption with HW decreased the incidence of renal cell carcinoma and suppressed tumor growth in Fe-NTA-treated in rats.
H₂ Mechanisms / Biological Findings
The source material reviewed did not establish a specific molecular hydrogen mechanism for the reported findings.
Authors’ Conclusion
The authors concluded that , drinking with HW attenuated Fe-NTA-induced renal injury and inhibited early tumor promotional events in rats.