Effect of hydrogen-rich water on the lactic acid level in metformin-treated diabetic rats under hypoxia.
Zhao C, Guo Y, Wang R, Cheng C, Chen X · The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2021
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
The study identified a possible biological mechanism for hydrogen rather than demonstrating a clinical treatment effect.
Hydrogen water diabetes study 2021: what the findings mean
This H2HUBB page translates the technical study record into consumer-friendly language while preserving the scientific details. This uncontrolled human study examined Effect of hydrogen-rich water on the lactic acid level in metformin-treated diabetic rats under hypoxia. The abstract describes Human participants; hydrogen delivered as hydrogen water. We found that the levels of lactic acid, pyruvate and lactate dehydrogenase were significantly lower in the blood of DMMHR group than DMMH group.
Publication: Zhao C, Guo Y, Wang R, Cheng C, Chen X, The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 2021.
What the researchers studied
The present study aims to investigate the impact of hydrogen-rich water on the lactic acid level in metformin-treated diabetic rats under hypoxia.
What effects did molecular hydrogen have?
Observed hydrogen effects: We found that the levels of lactic acid, pyruvate and lactate dehydrogenase were significantly lower in the blood of DMMHR group than DMMH group. Superoxide dismutase and glutathione levels in liver and heart were significantly higher in DMMH group after hydrogen-rich water treatment, while malondialdehyde and oxidized glutathione levels were decreased in DMMHR group when compared with DMMH group, which indicates that hydrogen-rich water could reduce oxidative stress (an imbalance in which reactive molecules exceed the body’s ability to control them). qPCR analysis demonstrated that that pro-apoptotic genes Bax/Caspase-3 were upregulated in DM group and metformin treatment suppressed their upregulation (DMM group).
Why these findings matter
This research helps explain how hydrogen may act at a biological level. It strengthens the scientific rationale for future therapeutic studies, but it does not show that patients will experience a clinical benefit.
How strong is this evidence?
This is preclinical animal evidence. It can show biological effects in a whole living system, but human effectiveness and dosing still require clinical trials.
Technical study details
- Publication type: Animal study
- Evidence type: Preclinical animal evidence
- Research model or population: Rat model
- Hydrogen method: Hydrogen water
Limitations and safety
Important limitations: The abstract alone may not report all methodological limitations; full-text review is required.
Safety information: The abstract did not provide detailed safety or adverse-event information.
Original study and H2HUBB research context
This page explains a published research record and does not turn one study into a medical recommendation. Read the original scientific source for the complete methods, statistics, and author conclusions. Compare this result with related evidence in the H2HUBB Molecular Hydrogen Research Library.