Effects of oral intake of hydrogen water on liver fibrogenesis in mice.
Yukinori Koyama, Kojiro Taura, Etsuro Hatano, Kazutaka Tanabe, Gen Yamamoto, Kojiro Nakamura, Kenya Yamanaka, Koji Kitamura, Masato Narita, Hiromitsu Nagata, Atsuko Yanagida, Taku Iida, Keiko Iwaisako, Hikohito Fujinawa, Shinji Uemoto · Hepatology research : the official journal of the Japan Society of Hepatology · 2014
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Independent study record
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H2HUBB TAKEAWAY
In C57BL/6 mice, culturing in the hydrogen-rich medium selectively suppressed the generation of hydroxyl radicals in hepatocytes and significantly suppressed hepatocyte death induced by antimycin A; however, it did not suppress hepatic stellate cell activation. These results are preclinical and suggest that molecular hydrogen did not improve the measured outcome. Further human research is needed to determine its clinical relevance.
What the Researchers Studied
The study examined this study aimed to investigate the effects of hydrogen water on liver fibrogenesis and the mechanisms underlying these effects.
How Molecular Hydrogen Was Used
C57BL/6 mice were fed with hydrogen water or control water, and subjected to carbon tetrachloride, thioacetamide and bile duct ligation treatments to induce liver fibrosis. Hepatocytes and hepatic stellate cells were isolated from mice and cultured with or without hydrogen to test the effects of hydrogen on reactive oxygen species-induced hepatocyte injuries or hepatic stellate cell activation.
What the Researchers Found
Oral intake of hydrogen water significantly suppressed liver fibrogenesis in the carbon tetrachloride and thioacetamide models, but these effects were not seen in the bile duct ligation model. Culturing in the hydrogen-rich medium selectively suppressed the generation of hydroxyl radicals in hepatocytes and significantly suppressed hepatocyte death induced by antimycin A; however, it did not suppress hepatic stellate cell activation.
H₂ Mechanisms / Biological Findings
Reported molecular-hydrogen-related mechanisms included this study aimed to investigate the effects of hydrogen water on liver fibrogenesis and the mechanisms underlying these effects.
Authors’ Conclusion
The authors concluded that hydrogen water protects hepatocytes from injury by scavenging hydroxyl radicals and thereby suppresses liver fibrogenesis in mice.