[Immunological Effect of Hydrogen Gas-Hydrogen Gas Improves Clinical Outcomes of Cancer Patients].
Junji Akagi · Gan to kagaku ryoho. Cancer & chemotherapy · 2018
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
The researchers found that the proportion of terminal PD-1+ CD8+ T cells was reduced in 35 out of 55 patients(63.6%)and was increased in 39 out of 55 patients(70.9%)after treatment with hydrogen gas. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen affected the outcomes measured in It has been reported that PD-1-expressing CD8+ T cells in the peripheral blood of cancer patients are associated with poor cancer prognosis. The researchers found that the proportion of terminal PD-1+ CD8+ T cells was reduced in 35 out of 55 patients(63.6%)and was increased in 39 out of 55 patients(70.9%)after treatment with hydrogen gas.
What the Researchers Studied
The researchers studied It has been reported that PD-1-expressing CD8+ T cells in the peripheral blood of cancer patients are associated with poor cancer prognosis. The study used a in vitro cell-culture laboratory experiment.
What Effects Did Molecular Hydrogen Have?
Out of another 26 patients treated with nivolumab, 14 patients treated with a combined therapy of hydrogen gas and nivolumab showed a significantly longer OS than the remaining 12 patients who were treated with nivolumab alone. The researchers found that the proportion of terminal PD-1+ CD8+ T cells was reduced in 35 out of 55 patients(63.6%)and was increased in 39 out of 55 patients(70.9%)after treatment with hydrogen gas. The authors concluded that these results suggest that hydrogen gas improves the prognosis of cancer patients by reducing the proportion of terminal PD-1+ CD8+ T cells.
Why These Findings Matter
These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
How Strong Is This Evidence?
This is laboratory evidence from a in vitro cell-culture laboratory experiment. It is most informative for the biological mechanisms, cellular responses, or biochemical outcomes directly measured.
Technical Study Details
H2HUBB classifies this publication as laboratory study with laboratory or cellular evidence. The research population or model was It has been reported that PD-1-expressing CD8+ T cells in the peripheral blood of cancer patients are associated with poor cancer prognosis. The reported sample size was 55. The study used a in vitro cell-culture laboratory experiment.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.