Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases.
Toru Ishibashi, Miki Ichikawa, Bunpei Sato, Shinji Shibata, Yuichi Hara, Yuji Naritomi, Ken Okazaki, Yasuharu Nakashima, Yukihide Iwamoto, Samon Koyanagi, Hiroshi Hara, Tetsuhiko Nagao · Molecular medicine reports · 2015
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In 3 patients, iL-17, whose concentration was high in Case 1, was reduced following H₂ treatment, and TNFα also decreased in Case 1. These findings add human evidence supporting molecular hydrogen's therapeutic potential for rheumatoid arthritis.
What the Findings Mean
H2HUBB reviewed how inhaled hydrogen gas affected the outcomes measured in 3 patients. IL-17, whose concentration was high in Case 1, was reduced following H₂ treatment, and TNFα also decreased in Case 1.
What the Researchers Studied
The researchers studied 3 patients.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 3% source-reported H₂ gas concentration; Source-reported hydrogen exposure: 3% source-reported H₂ gas concentration; reported treatment duration: 40 min. IL-17, whose concentration was high in Case 1, was reduced following H₂ treatment, and TNFα also decreased in Case 1. The authors concluded that in conclusion, H₂ administration reduced inflammation associated with psoriasis in the three cases examined and it may therefore be considered as a treatment strategy for psoriasis-associated skin lesions and arthritis. Immune cells, including leukocytes that infiltrate into psoriatic lesions, Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases TORU ISHIBASHI1,9, MIKI ICHIKAWA2, BUNPEI SATO3, SHINJI SHIBATA4, YUICHI HARA5, YUJI NARITOMI5, KEN OKAZAKI6, YASUHARU NAKASHIMA6, YUKIHIDE IWAMOTO6, SAMON KOYANAGI7, HIROSHI HARA5 and TETSUHIKO NAGAO8 Departments of 1Rheumatology and Orthopaedic Surgery, and 2Dermatology, Haradoi Hospital, Higashi‑ku, Fukuoka 813‑8588. 3MiZ Company, Fujisawa, Kanagawa 251‑0871; Departments of 4Radiology and 5Internal Medicine, Haradoi Hospital, Higashi‑ku, Fukuoka 813‑8588; 6Department of Orthopaedic Surgery, Kyushu University, Higashi‑Ku, Fukuoka 812‑8582; 7Department of Cardiology, Haradoi Hospital, Higashi‑ku, Fukuoka 813‑8588; 8Midorino Clinic, Higashi‑ku, Fukuoka 813‑0025, Japan Received May 31, 2014; Accepted April 9, 2015 DOI: 10.3892/mmr.2015.3707 Correspondence to: Dr Toru Ishibashi, 9Present address: Department of Rheumatology and Orthopaedic Surgery, Huis Ten Bosch Satellite, H₂ Clinic Hakata, 2‑1 Gion, Hakata‑ku, Fukuoka 812‑0038, Japan E‑mail: tishibashi@H₂‑lab.jp Key words: psoriasis, arthritis, molecular hydrogen, 7 ppm, H₂‑saline, H₂ gas ISHIBASHI et al: IMPROVEMENT OF PSORIASIS ‑ASSOCIATED ARTHRITIS AND SKIN LESIONS2758 overproduce ROS and activate the redox‑sensitive nuclear factor‑ κB‑dependent positive feedback loop (13), which, in turn, increases the transcription of the abovementioned pro‑inflammatory cytokines (14).
Why These Findings Matter
These findings add human evidence supporting molecular hydrogen's therapeutic potential for rheumatoid arthritis and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
This is human clinical evidence from a case report. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as case report with human clinical evidence. The research population or model was 3 patients. The reported sample size was 3. The hydrogen delivery method was inhaled hydrogen gas. The source-reported hydrogen concentration was 3% source-reported H₂ gas concentration. The reported treatment duration was 40 min.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base. The original scholarly source is available at https://www.spandidos-publications.com/10.3892/mmr.2015.3707/download.