Inhalation of 4% and 67% hydrogen ameliorates oxidative stress, inflammation, apoptosis, and necroptosis in a rat model of glycerol-induced acute kidney injury.
Jun-Li Xue, Bo-Yan Liu, Min Zhao, Meng-Yu Zhang, Ming-Yue Wang, Qian-Qian Gu, Xiao-Yi Zhang, Shu-Cun Qin · Medical gas research · 2023
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In rats, of scores for kidney appearance showed that for 4% H₂ inhalation, morphological lesions were alleviated in about 70% rats of this group, while for 67% H₂ inhalation, the number of improved rats was less (about 55%), but the remission effect was stronger and even some kidneys were restored to normal morphology ( Figure 2A and B ). These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how inhaled hydrogen gas affected the outcomes measured in rats. Of scores for kidney appearance showed that for 4% H₂ inhalation, morphological lesions were alleviated in about 70% rats of this group, while for 67% H₂ inhalation, the number of improved rats was less (about 55%), but the remission effect was stronger and even some kidneys were restored to normal morphology ( Figure 2A and B ).
What the Researchers Studied
The researchers studied rats. The study used a preclinical animal experiment. The comparison condition was control condition or baseline measurements.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 21% source-reported H₂ gas concentration; Source-reported hydrogen exposure: 21% source-reported H₂ gas concentration; reported treatment duration: 16 hours. Of scores for kidney appearance showed that for 4% H₂ inhalation, morphological lesions were alleviated in about 70% rats of this group, while for 67% H₂ inhalation, the number of improved rats was less (about 55%), but the remission effect was stronger and even some kidneys were restored to normal morphology ( Figure 2A and B ). The authors concluded that this study suggests that H₂ is a potential alternative therapy to prevent or minimize RM induced AKI possibly via its antioxidant, anti-inflammatory, anti-apoptotic and anti-necroptotic properties.
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The research population or model was rats. The study used a preclinical animal experiment. The hydrogen delivery method was inhaled hydrogen gas. The source-reported hydrogen concentration was 21% source-reported H₂ gas concentration. The reported treatment duration was 16 hours.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.