Inhalation of hydrogen gas attenuates airway inflammation and oxidative stress in allergic asthmatic mice.
Ning Zhang, Changwen Deng, Xingxing Zhang, Jingxi Zhang, Chong Bai · Asthma research and practice · 2018
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
In mice, hydrogen gas inhalation markedly upregulated the activity of decreased superoxide dismutase and significantly attenuated the increased level of malondialdehyde and myeloperoxidase. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how inhaled hydrogen gas affected the outcomes measured in mice. Hydrogen gas inhalation markedly upregulated the activity of decreased superoxide dismutase and significantly attenuated the increased level of malondialdehyde and myeloperoxidase.
What the Researchers Studied
The researchers studied mice. The study used a preclinical animal experiment. The comparison condition was control condition or baseline measurements.
What Effects Did Molecular Hydrogen Have?
Reported treatment duration: 60 min. Hydrogen gas inhalation markedly upregulated the activity of decreased superoxide dismutase and significantly attenuated the increased level of malondialdehyde and myeloperoxidase. The authors concluded that hydrogen gas inhalation improves lung function and protects established airway inflammation in the allergic asthmatic mice model which may be associated with the inhibition of oxidative stress process.
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The research population or model was mice. The study used a preclinical animal experiment. The hydrogen delivery method was inhaled hydrogen gas. The reported treatment duration was 60 min.
Limitations and Safety
Reported limitations: However, hydrogen gas had no effect on the other antioxidative enzymes, such as CAT, GSH and 8-hydroxy-2′-deoxyguanosine (8-OHdG), suggesting that hydrogen gas inhalation protected oxidative stress with limitations. Safety information: From this study, the researchers also noted that pure hydrogen gas inhalation had no significant effect on lung function, inflammatory mediators and oxidative production, suggesting that inhalation is a safe method for application. More clinical trials are needed to prove the clinical safety of its use and the protective effects of hydrogen gas at the bedside.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.