Inhalation of hydrogen gas attenuates cisplatin-induced ototoxicity via reducing oxidative stress.
Juan Qu, Xu Li, Juan Wang, Wenjuan Mi, Keliang Xie, Jianhua Qiu · International journal of pediatric otorhinolaryngology · 2012
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
In H(2) treatment was given twice with 2% H(2) inhalation for 60 min starting at 1h and 6h after cisplatin or saline injection, respectively, cisplatin significantly increased the levels of malondialdehyde (MDA) and 8-iso-prostaglandin F2α (8-iso-PGF2α) in serum and cochlear tissue, which was attenuated by H(2) treatment. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence oxidative-stress regulation.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen affected the outcomes measured in H(2) treatment was given twice with 2% H(2) inhalation for 60 min starting at 1h and 6h after cisplatin or saline injection, respectively. Cisplatin significantly increased the levels of malondialdehyde (MDA) and 8-iso-prostaglandin F2α (8-iso-PGF2α) in serum and cochlear tissue, which was attenuated by H(2) treatment.
What the Researchers Studied
The researchers studied H(2) treatment was given twice with 2% H(2) inhalation for 60 min starting at 1h and 6h after cisplatin or saline injection, respectively. The study used a human clinical study.
What Effects Did Molecular Hydrogen Have?
Reported treatment duration: 60 min. Cisplatin significantly increased the levels of malondialdehyde (MDA) and 8-iso-prostaglandin F2α (8-iso-PGF2α) in serum and cochlear tissue, which was attenuated by H(2) treatment. The authors concluded that these results demonstrate that H(2) is beneficial to cisplatin-induced ototoxicity via reducing oxidative stress.
Why These Findings Matter
These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence oxidative-stress regulation and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
This is human clinical evidence from a human clinical study. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as human clinical study with human clinical evidence. The research population or model was H(2) treatment was given twice with 2% H(2) inhalation for 60 min starting at 1h and 6h after cisplatin or saline injection, respectively. The study used a human clinical study. The reported treatment duration was 60 min.
Limitations and Safety
No separate limitations or safety findings were identified in the current-study source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.