Inhalation of hydrogen gas attenuates cognitive impairment in transient cerebral ischemia via inhibition of oxidative stress.
Pengfei Ge, Jingwei Zhao, Shulei Li, Yuchuan Ding, Fuwei Yang, Yinan Luo · Neurological research · 2012
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
In male Wistar rats, the neuronal density 3·3±2·1 cells/mm in CA1 region of the ischemic rats increased to 21·7±2·6 cells/mm after they were treated with hydrogen gas. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how inhaled hydrogen gas affected the outcomes measured in male Wistar rats. The neuronal density 3·3±2·1 cells/mm in CA1 region of the ischemic rats increased to 21·7±2·6 cells/mm after they were treated with hydrogen gas.
What the Researchers Studied
The researchers studied male Wistar rats. The study used a preclinical animal experiment.
What Effects Did Molecular Hydrogen Have?
2% inhaled H₂ concentration; reported treatment duration: 3 hours. The neuronal density 3·3±2·1 cells/mm in CA1 region of the ischemic rats increased to 21·7±2·6 cells/mm after they were treated with hydrogen gas. The authors concluded that inhalation of hydrogen gas could attenuate cognitive impairment in the ischemic rats. To investigate the effects of inhalation of hydrogen gas on cognitive impairment induced by transient cerebral ischemia and its potential mechanism. The levels of oxidative stress products malondialdehyde (MDA) and 8-iso-prostaglandin F2alpha, and the activities of anti-oxidative enzymes catalase and superoxide dismutase were measured to investigate the effects of inhalation of hydrogen gas on oxidative stress.
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The research population or model was male Wistar rats. The reported sample size was 20. The study used a preclinical animal experiment. The hydrogen delivery method was inhaled hydrogen gas. The reported hydrogen concentration was 2% inhaled H₂ concentration. The reported treatment duration was 3 hours.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.