Inhalation of Hydrogen Gas Is Beneficial for Preventing Contrast-Induced Acute Kidney Injury in Rats.
Koichiro Homma, Tadashi Yoshida, Maho Yamashita, Kei Hayashida, Matsuhiko Hayashi, Shingo Hori · Nephron. Experimental nephrology · 2015
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Independent study record
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H2HUBB TAKEAWAY
In rats, one day after the injection, serum levels of urea nitrogen were significantly lower in H₂ gas-inhaling CIAKI rats (17.6 ± 2.3 mg/dl) than those in control gas-treated CIAKI rats (36.0 ± 7.3 mg/dl), although they both were elevated as compared to untreated rats (14.9 ± 0.9 mg/dl). These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
The present study aimed at investigating the effect of a novel antioxidant, hydrogen (H₂) gas, on the severity of contrast-induced acute kidney injury (CIAKI) in a rat model.
How Molecular Hydrogen Was Used
During the injection of these reagents, the rats inhaled H₂ gas or control gas.
What the Researchers Found
One day after the injection, serum levels of urea nitrogen were significantly lower in H₂ gas-inhaling CIAKI rats (17.6 ± 2.3 mg/dl) than those in control gas-treated CIAKI rats (36.0 ± 7.3 mg/dl), although they both were elevated as compared to untreated rats (14.9 ± 0.9 mg/dl).
Authors’ Conclusion
The authors concluded that suggest that H₂ gas inhalation is effective in ameliorating the severity of CIAKI in rats by reducing renal cellular apoptosis and oxidative stress. © 2015 S. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.