Inhaled Gases for Neuroprotection of Neonates: A Review.
Youness Tolaymat, Sylvain Doré, Hudson W Griffin, Susana Shih, Mary E Edwards, Michael D Weiss · Frontiers in pediatrics · 2019
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
This narrative review examined the selected publications emphasize the emergence of promising inhaled gases that may improve neurologic survival and alleviate neurodevelopmental disability when combined with therapeutic hypothermia in the future. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
What the Findings Mean
H2HUBB reviewed this publication as a synthesis of molecular-hydrogen research and summarizes the outcomes emphasized by the authors. Preclinical studies show that inhaled gases are a promising adjunct therapy that could improve outcomes.
What the Researchers Studied
The authors reviewed the selected publications emphasize the emergence of promising inhaled gases that may improve neurologic survival and alleviate neurodevelopmental disability when combined with therapeutic hypothermia in the future.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 2.1% source-reported H₂ gas concentration; Source-reported hydrogen exposure: 2.1% source-reported H₂ gas concentration; reported treatment duration: 120 min. Preclinical studies show that inhaled gases are a promising adjunct therapy that could improve outcomes. The authors concluded that many inhaled agents have neuroprotective properties and could serve as an adjunct therapy to whole-body hypothermia.
Why These Findings Matter
The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
How Strong Is This Evidence?
This is review or synthesis evidence (narrative review).
Technical Study Details
H2HUBB classifies this publication as narrative review with review or synthesis evidence. The reported sample size was 7. The study used a narrative review. The hydrogen delivery method was inhaled hydrogen gas. The source-reported hydrogen concentration was 2.1% source-reported H₂ gas concentration. The reported treatment duration was 120 min.
Limitations and Safety
No separate limitations or safety findings were identified in the current-study source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.