Itraq-Based Quantitative Proteomic Analysis of Lungs in Murine Polymicrobial Sepsis with Hydrogen Gas Treatment.
Yingxue Bian, Chao Qin, Yuchang Xin, Yang Yu, Hongguang Chen, Guolin Wang, Keliang Xie, Yonghao Yu · Shock (Augusta, Ga.) · 2018
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Independent study record
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H2HUBB TAKEAWAY
In an animal model, sepsis-challenged animals had decreased survival rate, as well as had increased bacterial burden in blood, peritoneal lavage, and lung sample, which were significantly ameliorated by H₂ treatment. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
How Molecular Hydrogen Was Used
Thus, the findings provide an insight into the mechanism of H₂ treatment in sepsis by proteomic approach, which may be helpful to the clinic application of H₂ in patients with sepsis.
What the Researchers Found
Sepsis-challenged animals had decreased survival rate, as well as had increased bacterial burden in blood, peritoneal lavage, and lung sample, which were significantly ameliorated by H₂ treatment.
Authors’ Conclusion
These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.