Key Words: medical gas, antioxidant, carbon monoxide, hydrogen, nitric oxide Introduction The use of medical gases to treat oxidative stress is an exciting and evolving therap eutic possibility. Oxidative
The Editorial Secretariat of JCBN · Journal of Clinical Biochemistry and Nutrition · 2009
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
This narrative review examined the available molecular-hydrogen literature. Increased excretion of hydrogen in the breath after carbohydrate ingestion is c onsidered a consequence of bacterial fermentation in the colon [ 79, 80]. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
What the Findings Mean
H2HUBB reviewed this publication as a synthesis of molecular-hydrogen research and summarizes the outcomes emphasized by the authors. Hydrogen treatment significantly increased antioxidant enzyme activity, decreased lipid peroxide levels and decreased circulating proi nflammatory cytokine levels.
What the Researchers Studied
The authors reviewed key Words: medical gas, antioxidant, carbon monoxide, hydrogen, nitric oxide Introduction The use of medical gases to treat oxidative stress is an exciting and evolving therap eutic possibility.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 49% source-reported H₂ gas concentration; Source-reported hydrogen exposure: 49% source-reported H₂ gas concentration. Hydrogen treatment significantly increased antioxidant enzyme activity, decreased lipid peroxide levels and decreased circulating proi nflammatory cytokine levels. The authors concluded that these results suggested that dual gas therapy with CO and hydrogen may have more potent protective effects against cardiac cold ischemia/reperfusion injury compared to single treatment. Perioperative inhalation of 2% hydrogen mitigated intes tinal dysmotility following transplantation and reduced upregulation of inflammatory mediators, such as chemokine (C-C motif) ligand 2 (CCL2), interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α. The primary sources of oxidative injury include super- oxide anion (·O₂−) and hydrogen peroxide (H₂O₂), which undoubtedly play important ro les; however, these species also produce highly reactive hydroxyl radicals (·OH) and peroxynitrite (ONOO−) through the Haber-Weiss or Fenton reactions [2, 3].
Why These Findings Matter
The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
How Strong Is This Evidence?
This is review or synthesis evidence (narrative review).
Technical Study Details
H2HUBB classifies this publication as narrative review with review or synthesis evidence. The study used a narrative review. The hydrogen delivery method was inhaled hydrogen gas. The source-reported hydrogen concentration was 49% source-reported H₂ gas concentration.
Limitations and Safety
No separate limitations or safety findings were identified in the current-study source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base. The original scholarly source is available at https://www.jstage.jst.go.jp/article/jcbn/44/1/44_08-193R/_pdf.