Molecular Hydrogen: A Promising Adjunctive Strategy for the Treatment of the COVID-19.
Yingning Li, Zhen Wang, Naqi Lian, Yuzun Wang, Weiqiang Zheng, Keliang Xie · Frontiers in medicine · 2021
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
This narrative review examined the available molecular-hydrogen literature. In the rat model of the hemorrhagic shock and resuscitation, it was found that the lung tissue myeloperoxidase (MPO) activity was lower in the 2% hydrogen inhalation group compared than in the control group and the levels of inflammatory initiation cytokine, TNF-α, and IL-1β were also reduced. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
What the Findings Mean
H2HUBB reviewed this publication as a synthesis of molecular-hydrogen research and summarizes the outcomes emphasized by the authors. In the rat model of the hemorrhagic shock and resuscitation, it was found that the lung tissue myeloperoxidase (MPO) activity was lower in the 2% hydrogen inhalation group compared than in the control group and the levels of inflammatory initiation cytokine, TNF-α, and IL-1β were also reduced.
What the Researchers Studied
The authors reviewed molecular Hydrogen: A Promising Adjunctive Strategy for the Treatment of the COVID-19.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 2% source-reported H₂ gas concentration; Source-reported hydrogen exposure: 2% source-reported H₂ gas concentration; reported treatment duration: 45 min. In the rat model of the hemorrhagic shock and resuscitation, it was found that the lung tissue myeloperoxidase (MPO) activity was lower in the 2% hydrogen inhalation group compared than in the control group and the levels of inflammatory initiation cytokine, TNF-α, and IL-1β were also reduced. The authors concluded that russell et al. concluded that hydrogen acts on a variety of pathways to exert its anti-inflammatory and antioxidant effects in the treatment of chronic inflammatory lung diseases. This study mainly describes the mechanism of occurrence of the COVID-19, summarizes the therapeutic effects and underlying mechanisms of hydrogen on the critical disease, and analyzes the feasibility and potential therapeutic targets of hydrogen for the treatment of the COVID-19.
Why These Findings Matter
The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
How Strong Is This Evidence?
This is review or synthesis evidence (narrative review).
Technical Study Details
H2HUBB classifies this publication as narrative review with review or synthesis evidence. The study used a narrative review. The hydrogen delivery method was inhaled hydrogen gas. The source-reported hydrogen concentration was 2% source-reported H₂ gas concentration. The reported treatment duration was 45 min.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.