Molecular hydrogen decelerates rheumatoid arthritis progression through inhibition of oxidative stress.
Jia Meng, Pan Yu, Hui Jiang, Tao Yuan, Naicheng Liu, Jian Tong, Haiyan Chen, Nirong Bao, Jianning Zhao · American journal of translational research · 2016
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In a laboratory model, taken together, the data suggested that H₂ can directly neutralize OH and ONOO- to reduce oxidative stress. The authors concluded that taken together, the data suggested that H₂ can directly neutralize OH and ONOO- to reduce oxidative stress. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.
What the Researchers Tested
In vitro cell-culture laboratory experiment.
How Molecular Hydrogen Was Used
In this study, the researchers examined if the hydrogen could inhibit inflammation in a mouse model of collagen-induced arthritis (CIA) via oxidative stress on RA-FLSs. Moreover, to identify the mechanisms of action, the researchers evaluated the effect of hydrogen on RA-FLSs development and the expression of pro-inflammatory cytokines and signaling pathways. Based on the authors' result, H₂ enriched medium can increase super oxide dismutase (SOD) level following H₂O₂ treatment and decrease 8-hydroxy-2'-deoxyguanosine (8-OHdG) level.
What Molecular Hydrogen Changed
Taken together, the data suggested that H₂ can directly neutralize OH and ONOO- to reduce oxidative stress.
Proposed Mechanism
In this study, the researchers examined if the hydrogen could inhibit inflammation in a mouse model of collagen-induced arthritis (CIA) via oxidative stress on RA-FLSs. Moreover, to identify the mechanisms of action, the researchers evaluated the effect of hydrogen on RA-FLSs development and the expression of pro-inflammatory cytokines and signaling pathways.
Authors’ Conclusion
These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.