Hydrogen Research Study
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Laboratory or cellular evidenceLaboratory StudyOther or not reported

Protective effect of hydrogen-rich medium against high glucose-induced apoptosis of Schwann cells in vitro.

Yang Yu, Xiaoye Ma, Tao Yang, Bo Li, Keliang Xie, Daquan Liu, Guolin Wang, Yonghao Yu · Molecular medicine reports · 2015

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Independent study record

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H2HUBB Research Library branded molecular hydrogen research image
Primary topic Diabetes and Metabolic Health
Evidence type Laboratory or cellular evidence
Publication type Laboratory Study
Hydrogen method Other or not reported

H2HUBB TAKEAWAY

Previous studies have reported that oxidative stress and poly(ADP‐ribose) polymerase‐1 (PARP‐1) may be unifying factors for hyperglycemic injury. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.

What the Researchers Tested

The study examined in vitro cell-culture laboratory experiment.

How Molecular Hydrogen Was Used

The aim of the present study was to investigate the protective effects of hydrogen‐rich medium (HM) on high glucose (HG)‐mediated oxidative stress, PARP‐1 activation and the apoptosis of Schwann cells (SCs) in vitro.

What Molecular Hydrogen Changed

The aim of the present study was to investigate the protective effects of hydrogen‐rich medium (HM) on high glucose (HG)‐mediated oxidative stress, PARP‐1 activation and the apoptosis of Schwann cells (SCs) in vitro.

H₂ Mechanisms / Biological Findings

The aim of the present study was to investigate the protective effects of hydrogen‐rich medium (HM) on high glucose (HG)‐mediated oxidative stress, PARP‐1 activation and the apoptosis of Schwann cells (SCs) in vitro.

Authors’ Conclusion

The authors concluded that these results indicated that HM inhibited the HG‐induced‐oxidative stress‐associated caspase‐dependent and caspase‐independent apoptotic pathways in SCs.