Protective effect of hydrogen-rich medium against high glucose-induced apoptosis of Schwann cells in vitro.
Yang Yu, Xiaoye Ma, Tao Yang, Bo Li, Keliang Xie, Daquan Liu, Guolin Wang, Yonghao Yu · Molecular medicine reports · 2015
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
Previous studies have reported that oxidative stress and poly(ADP‐ribose) polymerase‐1 (PARP‐1) may be unifying factors for hyperglycemic injury. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.
What the Researchers Tested
The study examined in vitro cell-culture laboratory experiment.
How Molecular Hydrogen Was Used
The aim of the present study was to investigate the protective effects of hydrogen‐rich medium (HM) on high glucose (HG)‐mediated oxidative stress, PARP‐1 activation and the apoptosis of Schwann cells (SCs) in vitro.
What Molecular Hydrogen Changed
The aim of the present study was to investigate the protective effects of hydrogen‐rich medium (HM) on high glucose (HG)‐mediated oxidative stress, PARP‐1 activation and the apoptosis of Schwann cells (SCs) in vitro.
H₂ Mechanisms / Biological Findings
The aim of the present study was to investigate the protective effects of hydrogen‐rich medium (HM) on high glucose (HG)‐mediated oxidative stress, PARP‐1 activation and the apoptosis of Schwann cells (SCs) in vitro.
Authors’ Conclusion
The authors concluded that these results indicated that HM inhibited the HG‐induced‐oxidative stress‐associated caspase‐dependent and caspase‐independent apoptotic pathways in SCs.