Protective effect of hydrogen-rich medium against high glucose-induced apoptosis of Schwann cells in vitro.
Yang Yu, Xiaoye Ma, Tao Yang, Bo Li, Keliang Xie, Daquan Liu, Guolin Wang, Yonghao Yu · Molecular medicine reports · 2015
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In a laboratory model, the aim of the present study was to investigate the protective effects of hydrogen‐rich medium (HM) on high glucose (HG)‐mediated oxidative stress, PARP‐1 activation and the apoptosis of Schwann cells (SCs) in vitro. The authors concluded that these results indicated that HM inhibited the HG‐induced‐oxidative stress‐associated caspase‐dependent and caspase‐independent apoptotic pathways in SCs. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen was evaluated in this publication and summarizes the source-grounded findings below. The aim of the present study was to investigate the protective effects of hydrogen‐rich medium (HM) on high glucose (HG)‐mediated oxidative stress, PARP‐1 activation and the apoptosis of Schwann cells (SCs) in vitro.
What the Researchers Studied
The study used a in vitro cell-culture laboratory experiment.
What Effects Did Molecular Hydrogen Have?
The aim of the present study was to investigate the protective effects of hydrogen‐rich medium (HM) on high glucose (HG)‐mediated oxidative stress, PARP‐1 activation and the apoptosis of Schwann cells (SCs) in vitro. The authors concluded that these results indicated that HM inhibited the HG‐induced‐oxidative stress‐associated caspase‐dependent and caspase‐independent apoptotic pathways in SCs.
Why These Findings Matter
These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
How Strong Is This Evidence?
This is laboratory evidence from a in vitro cell-culture laboratory experiment. It is most informative for the biological mechanisms, cellular responses, or biochemical outcomes directly measured.
Technical Study Details
H2HUBB classifies this publication as laboratory study with laboratory or cellular evidence. The study used a in vitro cell-culture laboratory experiment.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.