Alleviation of exercise-induced injury by hydrogen inhalation via the reduction of oxidative stress and inflammation in athletes.
Xiaohong Zhang, Xiaofei Lu, Fan Li, Hao Gu, Xun Cheng, Jinhong Tang, Xiaodong Zhang, Jun Jiang, Li Feng, Xuemin Li · Journal of thoracic disease · 2025
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
After a single postexercise intervention, the H₂ group showed improved antioxidant capacity and reduced WBC and CRP levels. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
What the Findings Mean
H2HUBB reviewed how inhaled hydrogen gas was evaluated in this publication and summarizes the source-grounded findings below. After a single postexercise intervention, the H₂ group showed improved antioxidant capacity and reduced WBC and CRP levels.
What the Researchers Studied
The comparison condition was control condition or baseline measurements.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 66.7% source-reported H₂ gas concentration; Source-reported hydrogen exposure: 66.7% source-reported H₂ gas concentration; 3 L/min total gas flow (approximately 2001 mL/min H₂ component); reported treatment duration: 20 minutes. After a single postexercise intervention, the H₂ group showed improved antioxidant capacity and reduced WBC and CRP levels. The authors concluded that H₂ inhalation attenuates exercise-induced lung injury by reducing oxidative stress and inflammation. Although hydrogen (H₂) inhalation has been proposed as a nonpharmacological intervention with antioxidant and anti-inflammatory potential, its effects in the context of exercise remain poorly understood. Figure 2 Effects of hydrogen inhalation and infrared blanket intervention on oxidative stress biomarkers before winter training. (A) T-AOC, (B) SOD, and (C) MDA levels were measured in all three groups before winter training.
Why These Findings Matter
These findings add evidence supporting molecular hydrogen's therapeutic potential within the biological process and outcomes directly measured in this publication and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
H2HUBB classifies this publication as other research and interprets only the outcomes directly supported by the source record.
Technical Study Details
H2HUBB classifies this publication as other research with other supported evidence. The reported sample size was 46. The hydrogen delivery method was inhaled hydrogen gas. The source-reported hydrogen concentration was 66.7% source-reported H₂ gas concentration. The reported treatment duration was 20 minutes.
Limitations and Safety
Reported limitations: the absence of stratified analysis by sex represents a limitation of this study, and future research should consider sex hormones and menstrual cycle phases to delineate sex-based differences in recovery outcomes better.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.