Inhalation of molecular hydrogen increases breath acetone excretion during submaximal exercise: a randomized, single-blinded, placebo-controlled study.
Amane Hori, Masatoshi Ichihara, Hayata Kimura, Hisayoshi Ogata, Takaharu Kondo, Norio Hotta · Medical gas research · 2020
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In 10 participants, H₂ significantly augmented breath acetone and enhanced oxygen uptake during exercise (P < 0.01). These findings add human evidence that helps define the outcomes that did and did not change with molecular hydrogen in this study.
What the Findings Mean
H2HUBB reviewed how inhaled hydrogen gas affected the outcomes measured in 10 participants. H₂ significantly augmented breath acetone and enhanced oxygen uptake during exercise (P < 0.01).
What the Researchers Studied
The researchers studied 10 participants. The study used a randomized, placebo-controlled, crossover human clinical trial. The comparison condition was placebo.
What Effects Did Molecular Hydrogen Have?
Reported treatment duration: 35 minutes. H₂ significantly augmented breath acetone and enhanced oxygen uptake during exercise (P < 0.01). The authors concluded that these results suggest that inhaling H₂ gas promotes an exercise-induced increase in hepatic lipid metabolism. Recently, it has been suggested that molecular hydrogen (H₂) augments mitochondrial oxidative phosphorylation.
Why These Findings Matter
This publication adds useful evidence about where molecular hydrogen did and did not change the measured outcomes, helping define the larger therapeutic evidence base.
How Strong Is This Evidence?
This is human clinical evidence from a randomized, placebo-controlled, crossover human clinical trial. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as human clinical study with human clinical evidence. The research population or model was 10 participants. The reported sample size was 10. The study used a randomized, placebo-controlled, crossover human clinical trial. The hydrogen delivery method was inhaled hydrogen gas. The reported treatment duration was 35 minutes.
Limitations and Safety
Reported limitations: A limitation of the present study is the lack of a direct evidence to demonstrate the mechanisms that inhalation of H₂ gas augmented V Acetone during exercise.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.