Clinical Effects of Hydrogen Administration: From Animal and Human Diseases to Exercise Medicine
Garth L. Nicolson, Gonzalo Ferreira de Mattos, Robert Settineri, Carlos Costa, Rita Ellithorpe, Steven Rosenblatt, James La Valle, Antonio Jimenez, Shigeo Ohta · International Journal of Clinical Medicine · 2016
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In 8 patients (33 men and 16 women) with MetSyn [ 154 ], they found that H₂ treatment reduced levels of oxidation damage, increased activities of antioxidant enzymes, and reduced the levels of pro-inflammatory cytokines in serum and tissues [ 43 ]. Although the responses to radiotherapy were unchanged by the intake of H₂ -water, overall QOL scores were significantly improved in the H₂ -water group. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence vascular endothelial function.
What the Findings Mean
H2HUBB reviewed how hydrogen-rich water affected the outcomes measured in 8 patients (33 men and 16 women) with MetSyn [ 154 ]. They found that H₂ treatment reduced levels of oxidation damage, increased activities of antioxidant enzymes, and reduced the levels of pro-inflammatory cytokines in serum and tissues [ 43 ]. Although the responses to radiotherapy were unchanged by the intake of H₂ -water, overall QOL scores were significantly improved in the H₂ -water group.
What the Researchers Studied
The researchers studied 8 patients (33 men and 16 women) with MetSyn [ 154 ]. The study used a human clinical study.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 4% source-reported H₂ gas concentration; Source-reported hydrogen exposure: 4% source-reported H₂ gas concentration; via nasal cannula; reported treatment duration: 4 weeks. They found that H₂ treatment reduced levels of oxidation damage, increased activities of antioxidant enzymes, and reduced the levels of pro-inflammatory cytokines in serum and tissues [ 43 ]. Although the responses to radiotherapy were unchanged by the intake of H₂ -water, overall QOL scores were significantly improved in the H₂ -water group. The authors concluded that these results suggest that the inhalation of hydrogen gas in low-weight premature neonates could be an important method for reducing GMH and its consequences [ 263 ]. ROS/RNS species seem to play a central role in ischemia reperfusion injury mechanisms, and the rapid diffusion of molecular hydrogen and its ability to counteract ROS/RNS species, especially hydroxyl radicals (•OH) and peroxynitrites (ONOO − ) [ 5 ], has been proposed to significantly reduce damage during ischemia/reperfusion injury. Although part of the explanation in the improvement of lung grafts with hydrogen application is likely due to its effects in preventing ROS damage [ 102 ] [ 111 ], there is evidence that it also ameliorates the damage produced by pro-inflammatory agents and protecting against lipopolysaccharide induction damage [ 112 ] [ 113 ].
Why These Findings Matter
These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence vascular endothelial function and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
This is human clinical evidence from a human clinical study. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as human clinical study with human clinical evidence. The research population or model was 8 patients (33 men and 16 women) with MetSyn [ 154 ]. The reported sample size was 8. The study used a human clinical study. The hydrogen delivery method was hydrogen-rich water. The source-reported hydrogen concentration was 4% source-reported H₂ gas concentration. The reported treatment duration was 4 weeks.
Limitations and Safety
Safety information: The safety of H₂ in humans has been well documented in gas mixtures. In other deep diving studies H₂ was used during compression at 20 ATM to reduce bradycardia and other nervous and psychosensorimotor symptoms (high pressure nervous syndrome) without any long-term safety issues [ 52 ]. Hydrogen in other forms, such as H₂ -water, has not demonstrated any toxic or safety issues [ 1 ] [ 2 ].
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base. The original scholarly source is available at https://www.scirp.org/xml/62945.xml.