The potential utilizations of hydrogen as a promising therapeutic strategy against ocular diseases.
Ye Tao, Lei Geng, Wei-Wei Xu, Li-Min Qin, Guang-Hua Peng, Yi-Fei Huang · Therapeutics and clinical risk management · 2016
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
This narrative review examined the available molecular-hydrogen literature. It is the authors' hope that the protective effects of hydrogen, as evidenced by these pioneering studies, would enrich the authors' pharmacological knowledge about this natural element and cast light into the discovery of a novel therapeutic strategy against ocular diseases. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
What the Findings Mean
H2HUBB reviewed this publication as a synthesis of molecular-hydrogen research and summarizes the outcomes emphasized by the authors. It is the authors' hope that the protective effects of hydrogen, as evidenced by these pioneering studies, would enrich the authors' pharmacological knowledge about this natural element and cast light into the discovery of a novel therapeutic strategy against ocular diseases.
What the Researchers Studied
The authors reviewed the potential utilizations of hydrogen as a promising therapeutic strategy against ocular diseases.
What Effects Did Molecular Hydrogen Have?
Hydrogen is a promising gaseous agent that has come to the forefront of therapeutic research over the last few years. Hydrogen is so mild that it does not disturb metabolic oxidation–reduction reactions or disrupt the ROS involved in cell signaling. As highlighted earlier, the efficiency and safety of hydrogen in ameliorating ocular pathologies have been verified by a series of experiments. It is the authors' hope that the protective effects of hydrogen, as evidenced by these pioneering studies, would enrich the authors' pharmacological knowledge about this natural element and cast light into the discovery of a novel therapeutic strategy against ocular diseases. The authors concluded that therapeutic medical gas can act as a reasonable approach for the treatment of oxidative stress-related disease. Herein, the ophthalmological utilizations of hydrogen are systematically reviewed and the underlying mechanisms of hydrogen-induced beneficial effects are discussed.
Why These Findings Matter
The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
How Strong Is This Evidence?
This is review or synthesis evidence (narrative review).
Technical Study Details
H2HUBB classifies this publication as narrative review with review or synthesis evidence. The study used a narrative review.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.