Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury.
Kenji Dohi, Brian C Kraemer, Michelle A Erickson, Pamela J McMillan, Andrej Kovac, Zuzana Flachbartova, Kim M Hansen, Gul N Shah, Nader Sheibani, Therese Salameh, William A Banks · PloS one · 2014
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
These results show that molecular hydrogen given in drinking water reverses many of the sequelae of CCI and suggests that it could be an easily administered, highly effective treatment for TBI. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen was evaluated in this publication and summarizes the source-grounded findings below. These results show that molecular hydrogen given in drinking water reverses many of the sequelae of CCI and suggests that it could be an easily administered, highly effective treatment for TBI.
What the Researchers Studied
The comparison condition was control condition or baseline measurements.
What Effects Did Molecular Hydrogen Have?
Reported treatment duration: 45 minutes. These results show that molecular hydrogen given in drinking water reverses many of the sequelae of CCI and suggests that it could be an easily administered, highly effective treatment for TBI. Assessment of cellular respiration showed that exposure of brain pericytes to molecular hydrogen for 24 h increased basal respiration, reserve capacity, and non-mitochondrial respiration, where “non-mitochondrial respiration” is defined as oxygen use that occurs despite shutdown of the electron transport chain ( Figure 10 ).
Why These Findings Matter
These findings add evidence supporting molecular hydrogen's therapeutic potential within the biological process and outcomes directly measured in this publication and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
H2HUBB classifies this publication as other research and interprets only the outcomes directly supported by the source record.
Technical Study Details
H2HUBB classifies this publication as other research with other supported evidence. The reported sample size was 6. The reported treatment duration was 45 minutes.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.