Molecular hydrogen inhalation modulates resting metabolism in healthy females: findings from a randomized, double-blind, placebo-controlled crossover study.
Pavel Grepl, Michal Botek, Jakub Krejčí, Andrew McKune · Medical gas research · 2025
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In Twenty, physically active female participants aged 22, compared with placebo (ambient air), molecular hydrogen inhalation significantly decreased respiratory exchange ratio and ventilation across all intervals.
What the Researchers Studied
Twenty, physically active female participants aged 22.
How the Study Was Conducted
Randomized, double-blind, placebo-controlled human clinical trial.
How Molecular Hydrogen Was Used
Twenty, physically active female participants aged 22.1 ± 1.6 years who inhaled either molecular hydrogen or ambient air through a nasal cannula (300 mL/min) for 60 minutes while resting were included in this study.
What the Researchers Found
Compared with placebo (ambient air), molecular hydrogen inhalation significantly decreased respiratory exchange ratio and ventilation across all intervals.
Authors’ Conclusion
The authors concluded that in conclusion, 60 minutes of resting molecular hydrogen inhalation significantly increased resting fat oxidation, as evidenced by decreased respiratory exchange ratio, particularly in individuals with higher body fat percentages.