Molecular Hydrogen Inhibits Colorectal Cancer Growth via the AKT/SCD1 Signaling Pathway.
Xiangyan Zhang, Geru Tao, Ya'nan Zhao, Sijie Xing, Jie Jiang, Boyan Liu, Shucun Qin · BioMed research international · 2022
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Independent study record
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H2HUBB TAKEAWAY
In The effect of H₂ on the proliferation and apoptosis of RKO, SW480, and HCT116 CRC cell lines was assayed by CCK-8, colony formation, and flow cytometry assays, hydrogen treatment suppressed the proliferation of CRC cell lines independent of apoptosis, and the cell lines showed different responses to different doses of H₂. The authors concluded that further studies are warranted for clinical evaluation of H₂ as SCD1 inhibitor to target CRC. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.
What the Researchers Tested
The researchers sought to assess the potential effect of H₂ on colorectal cancer (CRC) in this study.
Laboratory Model
The effect of H₂ on the proliferation and apoptosis of RKO, SW480, and HCT116 CRC cell lines was assayed by CCK-8, colony formation, and flow cytometry assays.
How Molecular Hydrogen Was Used
The effect of H₂ on tumor growth was observed in xenograft implantation models (inhalation of 67% hydrogen two hours per day).
What Molecular Hydrogen Changed
Hydrogen treatment suppressed the proliferation of CRC cell lines independent of apoptosis, and the cell lines showed different responses to different doses of H₂.
Authors’ Conclusion
These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.