Protective effects of hydrogen enriched saline on liver ischemia reperfusion injury by reducing oxidative stress and HMGB1 release.
Yantao Liu, Liqun Yang, Kunming Tao, Marcela P Vizcaychipi, Dafydd M Lloyd, Xuejun Sun, Michael G Irwin, Daqing Ma, Weifeng Yu · BMC gastroenterology · 2014
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Independent study record
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H2HUBB TAKEAWAY
In rats, hydrogen enriched saline treatment significantly attenuated the severity of liver injury induced by ischemia-reperfusion. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
Hydrogen treatment was recently associated with down-regulation of the expression of HMGB1 and pro-inflammatory cytokines during sepsis and myocardial IRI, but it is not known whether hydrogen has an effect on HMGB1 in liver IRI.
How Molecular Hydrogen Was Used
Hydrogen enriched saline (2.5, 5 or 10 ml/kg) was injected intraperitoneally 10 minutes before hepatic reperfusion.
What the Researchers Found
Hydrogen enriched saline treatment significantly attenuated the severity of liver injury induced by ischemia-reperfusion. Hydrogen enriched saline treatment inhibited HMGB1 expression and release, reflecting a reduced local and systemic inflammatory response to hepatic ischemia reperfusion.
H₂ Mechanisms / Biological Findings
Hydrogen enriched saline treatment inhibited HMGB1 expression and release, reflecting a reduced local and systemic inflammatory response to hepatic ischemia reperfusion. Hydrogen treatment was recently associated with down-regulation of the expression of HMGB1 and pro-inflammatory cytokines during sepsis and myocardial IRI, but it is not known whether hydrogen has an effect on HMGB1 in liver IRI.
Authors’ Conclusion
The authors concluded that these results suggest that, in the authors' model, hydrogen enriched saline treatment is protective against liver ischemia-reperfusion injury. This effect may be mediated by both the anti-oxidative and anti-inflammatory effects of the solution.