Molecular hydrogen may enhance the production of testosterone hormone in male infertility through hormone signal modulation and redox balance.
Rahima Begum, Johny Bajgai, Ailyn Fadriquela, Cheol-Su Kim, Soo-Ki Kim, Kyu-Jae Lee · Medical hypotheses · 2018
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H2HUBB TAKEAWAY
Although moderate amounts of ROS are needed for normal sperm function, the higher amounts might decrease testosterone production. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
What the Publication Examined
Molecular hydrogen may enhance the production of testosterone hormone in male infertility through hormone signal modulation and redox balance.
How Molecular Hydrogen Was Addressed
Since the discovery of molecular hydrogen (H₂) as a selective scavenger of free radicals like reactive oxygen species (ROS) and reactive nitrogen species (RNS), numerous studies have proved the potential application of H₂ in therapeutic and preventative medicine. Moreover, H₂ can regulate the intracellular signal as a signal modulator. H₂ regulates intracellular MAPK downstream cAMP signal and Ca2+ signal as a signal modulator to antagonize ROS signaling.
What the Publication Reported
Although moderate amounts of ROS are needed for normal sperm function, the higher amounts might decrease testosterone production.