Molecular hydrogen modulates brain glutamate/GABA-glutamine cycle in overweight humans.
Darinka Korovljev, Jelena Ostojic, Nikola Todorovic, Sergej M Ostojic · Archives of medical science : AMS · 2023
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Independent study record
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H2HUBB TAKEAWAY
The researchers showed a possible hydrogen-driven upregulation of neurotransmitters involved in appetite stimulation leading to hunger suppression and weight loss. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
What the Publication Reported
The researchers showed a possible hydrogen-driven upregulation of neurotransmitters involved in appetite stimulation leading to hunger suppression and weight loss.
H₂ Mechanisms / Biological Findings
INTRODUCTION: the researchers evaluated whether 12-week intake of molecular hydrogen (H₂) in 5 overweight adults (3 women; age: 50.2 ±11.9 years, body mass index: 29.4 ±2.1 kg/m2) affects brain levels of the glutamate-glutamine-GABA cycle, critical amino acid neurotransmitters in the mechanism of neuronal activation during appetite regulation.
Authors’ Conclusion
The authors concluded that the researchers showed a possible hydrogen-driven upregulation of neurotransmitters involved in appetite stimulation leading to hunger suppression and weight loss. Further studies analyzing appetite-controlling metabolic pathways affected by H₂ would require monitoring of additional biomarkers of satiation and satiety during different feeding regimens.