The neuroprotective effects of electrolyzed reduced water and its model water containing molecular hydrogen and Pt nanoparticles.
Hanxu Yan, Taichi Kashiwaki, Takeki Hamasaki, Tomoya Kinjo, Kiichiro Teruya, Shigeru Kabayama, Sanetaka Shirahata · BMC proceedings · 2011
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
Human brain is the biggest energy consuming tissue in human body, electrolyzed reduced water (ERW) is a functional drinking water containing a lot of molecular hydrogen and a small amount of platinum nanoparticles (Pt NPs, Table 1 ). The authors concluded that eRW is beneficial for the prevention and alleviation of oxidative stress-induced human neurodegenerative diseases. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen affected the outcomes measured in Background Human brain is the biggest energy consuming tissue in human body. Electrolyzed reduced water (ERW) is a functional drinking water containing a lot of molecular hydrogen and a small amount of platinum nanoparticles (Pt NPs, Table 1 ).
What the Researchers Studied
The researchers studied Background Human brain is the biggest energy consuming tissue in human body. The study used a in vitro cell-culture laboratory experiment. The comparison condition was control condition or baseline measurements.
What Effects Did Molecular Hydrogen Have?
Electrolyzed reduced water (ERW) is a functional drinking water containing a lot of molecular hydrogen and a small amount of platinum nanoparticles (Pt NPs, Table 1 ). Molecular hydrogen could scavenge ROS and protected brain from oxidative stress [ 3 ]. MQ (NaOH) TI-200 ERW TI-9000 CW TI-9000 ERW pH 11.3 ± 0.1 11.6 ± 0.1 7.9 ± 0.1 9.6 ± 0.2 Dissolved Hydrogen (mM) 0 0.2– 0.45 0 0.1– 0.25 Dissolved Oxygen (μM) 0 3.1– 78.1 0 0– 21.9 Pt NPs (nM) 0 0.5– 12.8 0 0– 3.6 Redox potential value (mV) + 350 -659 – – Materials and methods In this research, the researchers used TI-200S ERW derived from 2 mM NaOH solution produced by a batch type electrolysis device and model waters containing molecular hydrogen and synthetic Pt NPs of 2-3 nm sizes as research models of ERW to examine the anti-oxidant capabilities of ERW on several kinds of neural cells such as PC12, N1E115, and serum free mouse embryo (SFME) cells. The authors concluded that eRW is beneficial for the prevention and alleviation of oxidative stress-induced human neurodegenerative diseases.
Why These Findings Matter
These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
How Strong Is This Evidence?
This is laboratory evidence from a in vitro cell-culture laboratory experiment. It is most informative for the biological mechanisms, cellular responses, or biochemical outcomes directly measured.
Technical Study Details
H2HUBB classifies this publication as laboratory study with laboratory or cellular evidence. The research population or model was Background Human brain is the biggest energy consuming tissue in human body. The study used a in vitro cell-culture laboratory experiment.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base. The original scholarly source is available at https://europepmc.org/article/PMC/PMC3285010.