Molecular hydrogen: potential in mitigating oxidative-stress-induced radiation injury 1.
Branislav Kura, Ashim K Bagchi, Pawan K Singal, Miroslav Barancik, Tyler W LeBaron, Katarina Valachova, Ladislav Šoltés, Ján Slezák · Canadian journal of physiology and pharmacology · 2019
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
This narrative review examined the available molecular-hydrogen literature. Irradiation of the rats caused a significant increase in lipid peroxidation, which was mitigated by pre-treatment of the animals with molecular hydrogen. The reviewed evidence supports molecular hydrogen's therapeutic potential. Additional well-designed studies are needed to clarify clinical safety and effectiveness.
Main Findings Across the Literature
Irradiation of the rats caused a significant increase in lipid peroxidation, which was mitigated by pre-treatment of the animals with molecular hydrogen.
Authors’ Conclusion
The authors concluded that suggest that the beneficial effects of molecular hydrogen may be through the activation of nuclear factor erythroid 2-related factor 2 pathway that promotes innate antioxidants and reduction of apoptosis, as well as inflammation.