Molecular hydrogen reduces acute exercise-induced inflammatory and oxidative stress status.
Jonatas E Nogueira, Patricia Passaglia, Clarissa M D Mota, Bruna M Santos, Marcelo E Batalhão, Evelin C Carnio, Luiz G S Branco · Free radical biology & medicine · 2018
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
In rats, otherwise, exercise caused an increased CREB phosphorylation which was attenuated by H₂. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
Rats
How Molecular Hydrogen Was Used
Recently, molecular hydrogen (H₂) has been described as a therapeutic gas able to reduced oxidative stress in a number of conditions. Therefore, the researchers tested the hypothesis that H₂ attenuates both inflammation and oxidative stress induced by acute physical exercise. Rats ran at 80% of their maximum running velocity on a closed treadmill inhaling either the H₂ gas (2% H₂, 21% O₂, balanced with N₂) or the control gas (0% H₂, 21% O₂, balanced with N₂) and were euthanized immediately or 3 h after exercise.
What the Researchers Found
Otherwise, exercise caused an increased CREB phosphorylation which was attenuated by H₂.
Biological or Mechanistic Findings
Recently, molecular hydrogen (H₂) has been described as a therapeutic gas able to reduced oxidative stress in a number of conditions.
Authors’ Conclusion
These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.