Shop Hydrogen Products
Hydrogen Research Study
← Back to Research Library
Preclinical animal evidenceAnimal studyOther or not reported

Stimulating fermentation by the prolonged acceleration of gut transit protects against decompression sickness.

Sébastien de Maistre, Nicolas Vallée, Sandrine Gaillard, Claude Duchamp, Jean-Eric Blatteau · Scientific reports · 2018

View Original Study View Full Text

Research-use notice

Independent study record

Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.

H2HUBB Research Library branded molecular hydrogen research image
Primary topic Gastrointestinal Health
Evidence type Preclinical animal evidence
Publication type Animal study
Hydrogen method Other or not reported

H2HUBB TAKEAWAY

In rats, pEG led to a significant increase in exhaled H₂ (35 ppm [10-73] compared with control 7 ppm [2-15]; p = 0.001). These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.

What the Findings Mean

H2HUBB reviewed how molecular hydrogen affected the outcomes measured in rats. PEG led to a significant increase in exhaled H₂ (35 ppm [10-73] compared with control 7 ppm [2-15]; p = 0.001).

What the Researchers Studied

The researchers studied rats. The study used a preclinical animal experiment. The comparison condition was control condition or baseline measurements.

What Effects Did Molecular Hydrogen Have?

Exhaled hydrogen was measured before the dive. PEG led to a significant increase in exhaled H₂ (35 ppm [10-73] compared with control 7 ppm [2-15]; p = 0.001).

Why These Findings Matter

These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.

How Strong Is This Evidence?

This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.

Technical Study Details

H2HUBB classifies this publication as animal study with preclinical animal evidence. The research population or model was rats. The study used a preclinical animal experiment.

Limitations and Safety

No separate limitations or safety findings were identified in the source text available to H2HUBB.

Original Study and H2HUBB Research Context

H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.

CONTINUE EXPLORING

Related Molecular Hydrogen Studies

Laboratory or cellular evidenceLaboratory StudyOther or not reported

Radioprotective effect of hydrogen in cultured cells and mice.

Liren Qian, Fei Cao, Jianguo Cui, Yuecheng Huang, Xiaojian Zhou, Shulin Liu, Jianming Cai · Free radical research · 2010

In It has been demonstrated that hydrogen can selectively reduce hydroxyl and peroxynitrite in vitro, this paper also shows that hydrogen can protect gastrointestinal endothelia from radiation-induced injury, decrease plasma malondialdehyde (MDA) intestinal 8-hydroxydeoxyguanosine…

Primary topic
Gastrointestinal Health
Delivery method
Other or not reported
Main limitation
Preclinical animal findings may not translate directly to human outcomes.
Study ID
DOI: 10.3109/10715760903468758
View Study View Source
Preclinical animal evidenceAnimal studyhydrogen-rich water

Zn-Fe primary battery-enabled controlled hydrogen release in stomach for improving insulin resistance in obesity-associated type 2 diabetes.

Boyan Liu, Peixun Lv, Xiaoyi Zhang, Chao Xia, Xinru Liu, Jingyu Liu, Junli Xue, Qianjun He, Shucun Qin · Bioactive materials · 2024

In mice, this work enhances the hydrolysis rate of Zn by constructing a Zn-Fe primary-battery micro-/nano-structure, and the H₂-releasing rate is adjusted by tuning the ratio of Zn to Fe. These preclinical findings add…

Primary topic
Diabetes and Metabolic Health
Delivery method
hydrogen-rich water
Main limitation
Preclinical animal findings may not translate directly to human outcomes.
Study ID
DOI: 10.1016/j.bioactmat.2023.11.003
View Study Full Text
Preclinical animal evidenceAnimal studyOther or not reported

Fructooligosaccharide feeding during gestation to pregnant mice provided excessive folic acid decreases maternal and female fetal oxidative stress by increasing intestinal microbe-derived hydrogen gas.

Asuka Okuda, Yuri Kintaka, Kenichi Tanabe, Toshiyuki Nakayama, Akito Shimouchi, Tsuneyuki Oku, Sadako Nakamura · Nutrition research (New York, N.Y.) · 2023

In mice, hydrogen gas concentrations in maternal livers and whole fetuses in EFA-FOS were significantly higher than those in CONT and EFA, respectively (P <.05). These preclinical findings add evidence supporting molecular hydrogen's therapeutic…

Primary topic
Gastrointestinal Health
Sample size
Not reported in abstract
Delivery method
Other or not reported
Main limitation
The intervention was fructooligosaccharide rather than direct molecular-hydrogen therapy, and mouse gestational findings may…
Study ID
DOI: 10.1016/j.nutres.2023.09.008
View Study View Source