Radioprotective effect of hydrogen in cultured cells and mice.
Liren Qian, Fei Cao, Jianguo Cui, Yuecheng Huang, Xiaojian Zhou, Shulin Liu, Jianming Cai · Free radical research · 2010
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In It has been demonstrated that hydrogen can selectively reduce hydroxyl and peroxynitrite in vitro, this paper also shows that hydrogen can protect gastrointestinal endothelia from radiation-induced injury, decrease plasma malondialdehyde (MDA) intestinal 8-hydroxydeoxyguanosine (8-OHDG) levels and increase plasma endogenous antioxidants in vivo. The authors concluded that it is suggested that hydrogen has a potential as an effective and safe radioprotective agent. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen affected the outcomes measured in It has been demonstrated that hydrogen can selectively reduce hydroxyl and peroxynitrite in vitro. This paper also shows that hydrogen can protect gastrointestinal endothelia from radiation-induced injury, decrease plasma malondialdehyde (MDA) intestinal 8-hydroxydeoxyguanosine (8-OHDG) levels and increase plasma endogenous antioxidants in vivo.
What the Researchers Studied
The researchers studied It has been demonstrated that hydrogen can selectively reduce hydroxyl and peroxynitrite in vitro. The study used a in vitro cell-culture laboratory experiment.
What Effects Did Molecular Hydrogen Have?
It has been demonstrated that hydrogen can selectively reduce hydroxyl and peroxynitrite in vitro. This paper demonstrates that treating cells with hydrogen before irradiation could significantly inhibit ionizing irradiation(IR)-induced Human Lymphocyte AHH-1 cells apoptosis and increase cells viability in vitro. This paper also shows that hydrogen can protect gastrointestinal endothelia from radiation-induced injury, decrease plasma malondialdehyde (MDA) intestinal 8-hydroxydeoxyguanosine (8-OHDG) levels and increase plasma endogenous antioxidants in vivo. The authors concluded that it is suggested that hydrogen has a potential as an effective and safe radioprotective agent.
Why These Findings Matter
These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
How Strong Is This Evidence?
This is laboratory evidence from a in vitro cell-culture laboratory experiment. It is most informative for the biological mechanisms, cellular responses, or biochemical outcomes directly measured.
Technical Study Details
H2HUBB classifies this publication as laboratory study with laboratory or cellular evidence. The research population or model was It has been demonstrated that hydrogen can selectively reduce hydroxyl and peroxynitrite in vitro. The study used a in vitro cell-culture laboratory experiment.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.