Will the hydrogen therapy be approved shortly?
Shigeo Ohta · Annals of translational medicine · 2020
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In 25 patients with acute cerebral infarction, H₂ treatment reduced oxidative stress, resulting in the mitigation of damages caused by ischemia-reperfusion ( 2 ). Twenty-five patients with acute cerebral infarction inhaled H₂ gas with no significant adverse effects, and were improved in oxygen saturation in comparison with 25 blinded control patients. These findings add human evidence supporting molecular hydrogen's therapeutic potential for recovery after myocardial infarction.
What the Findings Mean
H2HUBB reviewed how inhaled hydrogen gas affected the outcomes measured in 25 patients with acute cerebral infarction. H₂ treatment reduced oxidative stress, resulting in the mitigation of damages caused by ischemia-reperfusion ( 2 ). Twenty-five patients with acute cerebral infarction inhaled H₂ gas with no significant adverse effects, and were improved in oxygen saturation in comparison with 25 blinded control patients.
What the Researchers Studied
The researchers studied 25 patients with acute cerebral infarction. The study used a randomized human clinical trial. The comparison condition was control condition or baseline measurements.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 49% source-reported H₂ gas concentration; Source-reported hydrogen exposure: 49% source-reported H₂ gas concentration; via nasal cannula. H₂ treatment reduced oxidative stress, resulting in the mitigation of damages caused by ischemia-reperfusion ( 2 ). Twenty-five patients with acute cerebral infarction inhaled H₂ gas with no significant adverse effects, and were improved in oxygen saturation in comparison with 25 blinded control patients. MOLECULAR HYDROGEN EXHIBITS GREAT EFFICACY AGAINST ISCHEMIA-REPERFUSION INJURY: Because ischemia-reperfusion induces strong oxidative stress, to overcome the ischemia-reperfusion injuries should be one of the serious issues in many clinical treatments. Carbon monoxide (CO), hydrogen sulfide (H₂ S), and nitric oxide (·NO) play important roles as signaling molecules at lower levels; however, they are highly toxic molecules at higher concentrations.
Why These Findings Matter
These findings add human evidence supporting molecular hydrogen's therapeutic potential for recovery after myocardial infarction and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
This is human clinical evidence from a randomized human clinical trial. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as human clinical study with human clinical evidence. The research population or model was 25 patients with acute cerebral infarction. The reported sample size was 5. The study used a randomized human clinical trial. The hydrogen delivery method was inhaled hydrogen gas. The source-reported hydrogen concentration was 49% source-reported H₂ gas concentration.
Limitations and Safety
Safety information: Importantly for an actual application, the biological safety of H₂ was revealed by the inhalation of an extremely high concentration of H₂ gas in an exotic breathing gas mixture, Hydreliox, which is composed of 49% H₂, 50% helium and 1% O₂. Solubilized H₂ (H₂ infused in water; termed H₂ -water) may be convenient in potable, and can be administered by a safe way by drinking H₂ -water ( 5 ). H₂ inhalation during percutaneous coronary intervention was safe and feasible, and promoted left ventricular reverse remodeling at 6 months after ST-elevated myocardial infarction ( 17 ).
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.