Anti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation.
B Gharib, S Hanna, O M Abdallahi, H Lepidi, B Gardette, M De Reggi · Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie · 2001
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
This publication examined molecular hydrogen using the study design reported by the authoritative source. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
What the Publication Examined
Anti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation.
How Molecular Hydrogen Was Addressed
Molecular hydrogen reacts with the hydroxyl radical, a highly cytotoxic species produced in inflamed tissues. It has been suggested therefore to use gaseous hydrogen in a new anti-inflammatory strategy. The researchers tested this idea, with the aid of the equipment and skills of COMEX SA in Marseille, a group who experiments with oxygen-hydrogen breathing mixtures for professional deep-sea diving.
What the Publication Reported
The treatment had significant protective effects towards liver injury, namely decreased fibrosis, improvement of hemodynamics, increased NOSII activity, increased antioxidant enzyme activity, decreased lipid peroxide levels and decreased circulating TNF-alpha levels.
H₂ Mechanisms / Biological Findings
It has been suggested therefore to use gaseous hydrogen in a new anti-inflammatory strategy.
Authors’ Conclusion
The authors concluded that these findings indicate that the proposed anti-inflammatory strategy deserves further attention.