Oral administration of mannitol may be an effective treatment for ischemia-reperfusion injury.
Shulin Liu, Qiang Sun, Hengyi Tao, Xuejun Sun · Medical hypotheses · 2010
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In an animal model, bacteria in the large intestinal can produce endogenous hydrogen, and the authors' preliminary experiments revealed that oral administration of mannitol in humans and animals can significantly increase the level of endogenous hydrogen. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how inhaled hydrogen gas was evaluated in this publication and summarizes the source-grounded findings below. Bacteria in the large intestinal can produce endogenous hydrogen, and the authors' preliminary experiments revealed that oral administration of mannitol in humans and animals can significantly increase the level of endogenous hydrogen.
What the Researchers Studied
The study used a preclinical animal experiment.
What Effects Did Molecular Hydrogen Have?
Inhalation of hydrogen gas has been proved to be an effective treatment for ischemia-reperfusion injury. Bacteria in the large intestinal can produce endogenous hydrogen, and the authors' preliminary experiments revealed that oral administration of mannitol in humans and animals can significantly increase the level of endogenous hydrogen. There has been considerable evidence of hydrogen's protective effect to diseases related to oxidative injury, such as the ischemia-reperfusion injury of the brain, liver and heart.
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The study used a preclinical animal experiment. The hydrogen delivery method was inhaled hydrogen gas.
Limitations and Safety
No separate limitations or safety findings were identified in the current-study source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.