Oral intake of hydrogen-rich water inhibits intimal hyperplasia in arterialized vein grafts in rats.
Qiang Sun, Tomohiro Kawamura, Kosuke Masutani, Ximei Peng, Qing Sun, Donna B Stolz, John P Pribis, Timothy R Billiar, Xuejun Sun, Christian A Bermudez, Yoshiya Toyoda, Atsunori Nakao · Cardiovascular research · 2012
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Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In rat smooth muscle cell (A7r5) cultures, hydrogen treatment for 24 h reduced smooth muscle cell migration. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
The researchers investigated the efficacy of oral administration of hydrogen-rich water (HW) for prevention of intimal hyperplasia.
How Molecular Hydrogen Was Used
Molecular hydrogen was administered as the researchers investigated the efficacy of oral administration of hydrogen-rich water (hw) for prevention of intimal hyperplasia.
What the Researchers Found
In rat smooth muscle cell (A7r5) cultures, hydrogen treatment for 24 h reduced smooth muscle cell migration.
H₂ Mechanisms / Biological Findings
Hydrogen potently protects organs and cells from many insults via its anti-inflammatory and antioxidant properties.
Authors’ Conclusion
The authors concluded that drinking HW significantly reduced neointima formation after vein grafting in rats. Drinking HW may have therapeutic value as a novel therapy for intimal hyperplasia and could easily be incorporated into daily life.