Oxidative stress-induced NCC activation in the development of nocturnal polyuria in mice: Therapeutic potential of a sustained hydrogen-releasing silicon-based agent.
Yosuke Sekii, Hiroshi Kiuchi, Kentaro Takezawa, Norichika Ueda, Takahiro Imanaka, Sohei Kuribayashi, Koichi Okada, Shinichiro Fukuhara, Ryoichi Imamura, Hiromistu Negoro, Yuki Kobayashi, Hikaru Kobayashi, Norio Nonomura · Biochemistry and biophysics reports · 2025
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In mice, nocturnal polyuria is a prevalent condition associated with significant deterioration in quality of life and increased risk of mortality. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how inhaled hydrogen gas affected the outcomes measured in mice. Nocturnal polyuria is a prevalent condition associated with significant deterioration in quality of life and increased risk of mortality.
What the Researchers Studied
The researchers studied mice. The study used a preclinical animal experiment. The comparison condition was control condition or baseline measurements.
What Effects Did Molecular Hydrogen Have?
Reported treatment duration: 2 weeks. Nocturnal polyuria is a prevalent condition associated with significant deterioration in quality of life and increased risk of mortality. The authors concluded that these findings highlight the critical contributions of intrarenal oxidative stress to the pathogenesis of nocturnal polyuria and suggest that silicon-based agent holds promise for clinical application as a novel treatment for nocturnal polyuria. Hydrogen is effective for the treatment of several diseases in clinical research and is a promising agent owing to its anti-oxidative stress properties. Its ability to generate hydrogen through ingestion has been explored as a mechanism for mitigating oxidative damage.
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The research population or model was mice. The study used a preclinical animal experiment. The hydrogen delivery method was inhaled hydrogen gas. The reported treatment duration was 2 weeks.
Limitations and Safety
Safety information: However, inhalation of hydrogen gas for chronic diseases is difficult to conduct at home because hydrogen gas inhalation machines have safety and portability issues for home use.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.