Hydrogen/oxygen mixed gas inhalation improves disease severity and dyspnea in patients with Coronavirus disease 2019 in a recent multicenter, open-label clinical trial.
Guan WJ, Wei CH, Chen AL, Sun XC, Guo GY, Zou X, Shi JD, Lai PZ, Zheng ZG, Zhong NS · Journal of thoracic disease · 2020
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
In 21 patients with laboratory-confirmed COVID-19 from seven hospitals in China, inhalation of hydrogen/oxygen mixed gas (H₂ -O₂ ) might have a role in the treatment of COVID-19 given the decreased resistance compared with room air when passing through the airways. This open-label study suggests therapeutic potential, while larger randomized, placebo-controlled studies are needed to confirm the finding.
What the Researchers Studied
The study examined 21 patients with laboratory-confirmed COVID-19 from seven hospitals in China.
How Molecular Hydrogen Was Used
inhaled hydrogen gas.
What the Researchers Found
Inhalation of hydrogen/oxygen mixed gas (H₂ -O₂ ) might have a role in the treatment of COVID-19 given the decreased resistance compared with room air when passing through the airways.
H₂ Mechanisms / Biological Findings
The source material reviewed did not establish a specific molecular hydrogen mechanism for the reported findings.
Authors’ Conclusion
A distinct authors’ conclusion was not available in the source material reviewed by H2HUBB.
Limitations Reported by the Authors
The study was limited by the open-label design and variable duration of H₂ -O₂ inhalation due to the urgency.