Perioperatively Inhaled Hydrogen Gas Diminishes Neurologic Injury Following Experimental Circulatory Arrest in Swine.
Alexis R Cole, Dorothy A Perry, Ali Raza, Arthur P Nedder, Elizabeth Pollack, William L Regan, Sarah J van den Bosch, Brian D Polizzotti, Edward Yang, Daniel Davila, Onur Afacan, Simon K Warfield, Yangming Ou, Brenda Sefton, Allen D Everett, Jeffrey J Neil, Hart G W Lidov, John E Mayer, John N Kheir · JACC. Basic to translational science · 2019
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In an animal model, this study used a swine model of mildly hypothermic prolonged circulatory arrest and found that the addition of 2.4% inhaled hydrogen gas to inspiratory gases during and after the ischemic insult significantly decreased neurologic and renal injury compared with controls. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how inhaled hydrogen gas was evaluated in this publication and summarizes the source-grounded findings below. This study used a swine model of mildly hypothermic prolonged circulatory arrest and found that the addition of 2.4% inhaled hydrogen gas to inspiratory gases during and after the ischemic insult significantly decreased neurologic and renal injury compared with controls.
What the Researchers Studied
The study used a preclinical animal experiment.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 1.3% source-reported H₂ gas concentration; Source-reported hydrogen exposure: 1.3% source-reported H₂ gas concentration; reported treatment duration: 7 days. This study used a swine model of mildly hypothermic prolonged circulatory arrest and found that the addition of 2.4% inhaled hydrogen gas to inspiratory gases during and after the ischemic insult significantly decreased neurologic and renal injury compared with controls. The authors concluded that perspectives COMPETENCY IN MEDICAL KNOWLEDGE: The use of inhaled hydrogen gas to diminish ischemic injury has been applied successfully in several rodent models and was recently described in humans following stroke, acute myocardial infarction, and cardiac arrest.
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The reported sample size was 10. The study used a preclinical animal experiment. The hydrogen delivery method was inhaled hydrogen gas. The source-reported hydrogen concentration was 1.3% source-reported H₂ gas concentration. The reported treatment duration was 7 days.
Limitations and Safety
Safety information: Second, H₂ appears to be well tolerated at the doses tested. A demonstration of safety in healthy volunteers is warranted, followed by a prospective study of hydrogen inhalation during congenital heart surgery and other clinical scenarios.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.