PPARα contributes to the therapeutic effect of hydrogen gas against sepsis-associated encephalopathy with the regulation to the CREB-BDNF signaling pathway and hippocampal neuron plasticity-related gene expression.
Yuanyuan Bai, Qingqing Han, Beibei Dong, Huaying Lin, Yi Jiang, Xinyue Zhang, Hongguang Chen, Yonghao Yu · Brain research bulletin · 2022
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Independent study record
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H2HUBB TAKEAWAY
The results showed the expression of PPARα was decreased in SAE mice and that activation of PPARα in septic mice improved the survival rate and alleviated cognitive dysfunction. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.
What the Researchers Tested
Laboratory experiment
How Molecular Hydrogen Was Used
After the injection of GW6471 (the PPARα inhibitor) or GW7647 (the PPARα agonist) or saline, C57BL/6 J mice were subjected to cecal ligation and puncture (CLP) or sham operation, then treated with 2% H₂ by inhalation for 1 h after the operation.
What Molecular Hydrogen Changed
The results showed the expression of PPARα was decreased in SAE mice and that activation of PPARα in septic mice improved the survival rate and alleviated cognitive dysfunction.
Proposed Mechanism
The molecular mechanism of hydrogen (H₂) administration, as a promising strategy for the treatment of SAE, is still unclear.
Authors’ Conclusion
These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.