Protection by Inhaled Hydrogen Therapy in a Rat Model of Acute Lung Injury can be Tracked in vivo Using Molecular Imaging.
Said H Audi, Elizabeth R Jacobs, Xiao Zhang, Amadou K S Camara, Ming Zhao, Meetha M Medhora, Benjamin Rizzo, Anne V Clough · Shock (Augusta, Ga.) · 2017
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In rats, hyperoxia exposure increased glutathione content in lung homogenate (36%) more than hyperoxia+H₂ (21%), consistent with increases measured in Tc-HMPAO lung uptake. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
Rats
How Molecular Hydrogen Was Used
Inhaled hydrogen gas (H₂) provides protection in rat models of human acute lung injury (ALI). Rats were exposed to room air (normoxia), 98% O₂ + 2% N₂ (hyperoxia) or 98% O₂ + 2% H₂ (hyperoxia+H₂) for up to 60 h.
What the Researchers Found
Hyperoxia exposure increased glutathione content in lung homogenate (36%) more than hyperoxia+H₂ (21%), consistent with increases measured in Tc-HMPAO lung uptake.
Authors’ Conclusion
The authors concluded that the potential utility of these SPECT biomarkers for in vivo assessment of key cellular pathways in the pathogenesis of ALI and for monitoring responses to therapies. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.