Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy.
Qingxi Yang, Guangdong Ji, Rongtao Pan, Yinghui Zhao, Peng Yan · Molecular and clinical oncology · 2017
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
These findings add human evidence that helps define the outcomes that did and did not change with molecular hydrogen in this study.
What the Findings Mean
The ALT levels in the hydrogen-rich water group before and after chemotherapy were 28.72±1.6 and 31.28±1.47 IU/l, respectively; the differ – ence was not statistically significant (P=0.46).
What the Researchers Studied
The study used a randomized, placebo-controlled human clinical trial. The comparison condition was placebo.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 3.48 ± 0.10 µM H₂ (≈0.007 ± 0 mg/L); Source-reported hydrogen exposure: 3.48 ± 0.10 µM H₂ (≈0.007 ± 0 mg/L). The ALT levels in the hydrogen-rich water group before and after chemotherapy were 28.72±1.6 and 31.28±1.47 IU/l, respectively; the differ – ence was not statistically significant (P=0.46). Hydrogen is a naturally existing colorless, tasteless and odorless gas, and its protective effect against oxidative damage to the brain, liver, kidney and other major organs has been previously described (5). As reported, hydrogen -rich water may reduce hepatic injury through reducing oxidative stress and high mobility group box 1 ( 27).
Why These Findings Matter
This publication adds useful evidence about where molecular hydrogen did and did not change the measured outcomes, helping define the larger therapeutic evidence base.
How Strong Is This Evidence?
This is human clinical evidence from a randomized, placebo-controlled human clinical trial. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as human clinical study with human clinical evidence. The reported sample size was 152. The study used a randomized, placebo-controlled human clinical trial. The hydrogen delivery method was hydrogen-rich water. The source-reported hydrogen concentration was 3.48 ± 0.10 µM H₂ (≈0.007 ± 0 mg/L). The source-reported hydrogen exposure was 3.48 ± 0.10 µM H₂ (≈0.007 ± 0 mg/L).
Limitations and Safety
Safety information: Solubilized hydrogen (hydrogen-rich water) is a portable, easily administered and safe means of delivering molecular hydrogen (6).
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base. The original scholarly source is available at https://www.spandidos-publications.com/10.3892/mco.2017.1409/download.