Protective effects of hydrogen gas against sepsis-induced acute lung injury via regulation of mitochondrial function and dynamics.
Aili Dong, Yang Yu, Yanyan Wang, Can Li, Hongguang Chen, Yingxue Bian, Peng Zhang, Yungang Zhao, Yonghao Yu, Keliang Xie · International immunopharmacology · 2018
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In By using cecal ligation and puncture (CLP), a classic septic model, the researchers explored the role of 2% H₂ treatment in sepsis-induced acute lung injury (ALI) linked to mitochondrial function and, therapy with 2% H₂ increased PaO2/FiO2 ratios, MMP and ATP levels, RCR, complex I activity and MFN2 expression but decreased histological score and Drp1 levels in the presence of sepsis. These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study.
What the Findings Mean
Therapy with 2% H₂ increased PaO2/FiO2 ratios, MMP and ATP levels, RCR, complex I activity and MFN2 expression but decreased histological score and Drp1 levels in the presence of sepsis.
What the Researchers Studied
The study used a randomized human clinical trial. The comparison condition was control condition or baseline measurements.
What Effects Did Molecular Hydrogen Have?
2% inhaled H₂ concentration. Therapy with 2% H₂ increased PaO2/FiO2 ratios, MMP and ATP levels, RCR, complex I activity and MFN2 expression but decreased histological score and Drp1 levels in the presence of sepsis. The authors concluded that these data indicated that inhalation of 2% H₂ to regulate mitochondrial function and dynamics may be a promising therapeutic strategy for lung injuries induced by severe sepsis. Hydrogen gas (H₂), which has selective anti-oxidative effects, can be effectively used to treat septic mice.
Why These Findings Matter
These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
This is human clinical evidence from a randomized human clinical trial. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as human clinical study with human clinical evidence. The study used a randomized human clinical trial. The hydrogen delivery method was inhaled hydrogen gas. The reported hydrogen concentration was 2% inhaled H₂ concentration.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.