Recent advances in the neuroprotective effects of medical gases.
Yue-Zhen Wang, Ting-Ting Li, Hong-Ling Cao, Wan-Chao Yang · Medical gas research · 2019
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
This narrative review examined the available molecular-hydrogen literature. Medical gases include common gases, such as oxygen, hydrogen and carbon dioxide; hydrogen sulphide and nitric oxide that have been considered toxic; volatile anesthetic gases, such as isoflurane and sevoflurane; and inert gases like helium, argon, and xenon. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
What the Findings Mean
H2HUBB reviewed this publication as a synthesis of molecular-hydrogen research and summarizes the outcomes emphasized by the authors. Medical gases include common gases, such as oxygen, hydrogen and carbon dioxide; hydrogen sulphide and nitric oxide that have been considered toxic; volatile anesthetic gases, such as isoflurane and sevoflurane; and inert gases like helium, argon, and xenon.
What the Researchers Studied
The authors reviewed recent advances in the neuroprotective effects of medical gases.
What Effects Did Molecular Hydrogen Have?
Medical gases include common gases, such as oxygen, hydrogen and carbon dioxide; hydrogen sulphide and nitric oxide that have been considered toxic; volatile anesthetic gases, such as isoflurane and sevoflurane; and inert gases like helium, argon, and xenon. The authors concluded that this suggests that neuroprotection may be necessany in the treatment of multiple disease models. 37 Consuming hydrogen water has been shown to prevent the apoptosis of cerebral microvascular endothelial cells through the down-regulation of the phosphatidylinositol 3-hydroxy kinase/protein kinase B/glycogen synthase kinase 3β (PI3K/Akt/Gsk3β) pathway, leading to a decrease in the extent of secondary brain injury. 39 Hydrogen water inhibits the production of IL-1β and reactive oxygen species, reduces the inflammatory reaction, and subsequently decreases the depression behavioural scores.
Why These Findings Matter
The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
How Strong Is This Evidence?
This is review or synthesis evidence (narrative review).
Technical Study Details
H2HUBB classifies this publication as narrative review with review or synthesis evidence. The study used a narrative review. The hydrogen delivery method was inhaled hydrogen gas.
Limitations and Safety
No separate limitations or safety findings were identified in the current-study source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.