Recent progress toward hydrogen medicine: potential of molecular hydrogen for preventive and therapeutic applications.
Shigeo Ohta · Current pharmaceutical design · 2011
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
This narrative review examined the available molecular-hydrogen literature. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
What the Findings Mean
H2HUBB reviewed this publication as a synthesis of molecular-hydrogen research and summarizes the outcomes emphasized by the authors. 3% hydrogen gas treatment did not decrease ●OH, protein carbonyl, and 8-hydroxydeoxyguanosine, suggesting that scavenging ●OH might not be responsible for these effects of hydrogen gas in this study [ 54 ].
What the Researchers Studied
The authors reviewed recent progress toward hydrogen medicine: potential of molecular hydrogen for preventive and therapeutic applications.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 49% source-reported H₂ gas concentration; Source-reported hydrogen exposure: 49% source-reported H₂ gas concentration; via nasal cannula. 3% hydrogen gas treatment did not decrease ●OH, protein carbonyl, and 8-hydroxydeoxyguanosine, suggesting that scavenging ●OH might not be responsible for these effects of hydrogen gas in this study [ 54 ]. The authors concluded that cLOSING REMARKS: ISSUES TO BE DISSOLVED IN THE FUTURE: 13 In the authors' first report published in 2007, the researchers indicated that H₂ reacted with strong reactive oxygen/nitrogen species, including ●OH and ONOO – in cell-free reactions. Clinical tests have revealed that drinking hydrogen water reduced oxidative stress markers in patients with type 2 diabetes [ 144 ] or subjects with potential metabolic syndrome [ 145 ] and influenced glucose [ 144 ] and cholesterol metabolism [ 145 ]. Since inhaled hydrogen gas acts more rapidly, it may be suitable for defense against acute oxidative stress.
Why These Findings Matter
The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
How Strong Is This Evidence?
This is review or synthesis evidence (narrative review).
Technical Study Details
H2HUBB classifies this publication as narrative review with review or synthesis evidence. The study used a narrative review. The hydrogen delivery method was inhaled hydrogen gas. The source-reported hydrogen concentration was 49% source-reported H₂ gas concentration.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.