Relationship between Exhaled Hydrogen and Human Neutrophil Function in the Japanese General Population
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In 656 community participants, exhaled hydrogen was positively correlated with stimulated neutrophil ROS production in men younger than 60, but the same pattern was not seen in older men or women. This is an observational endogenous-hydrogen study, not a hydrogen-treatment trial.
What the Findings Mean
The authors interpreted higher endogenous hydrogen as potentially responsive to oxidative stress, but the cross-sectional association does not demonstrate therapeutic benefit.
What the Researchers Studied
Researchers measured exhaled hydrogen and neutrophil reactive oxygen species production in participants from the 2007 Iwaki Health Promotion Project after excluding several major medical and medication-related confounders.
What Effects Did Molecular Hydrogen Have?
A positive correlation between exhaled hydrogen concentration and stimulated neutrophil ROS production was observed in men under 60 (P<0.05); the association was not observed across the other age/sex groups.
Why These Findings Matter
The authors interpreted higher endogenous hydrogen as potentially responsive to oxidative stress, but the cross-sectional association does not demonstrate therapeutic benefit.
How Strong Is This Evidence?
Human cross-sectional observational study.
Technical Study Details
Model: Japanese general-population cohort from the Iwaki Health Promotion Project
Sample: 656 participants: 252 men and 404 women
DOI: 10.32216/hirosakiigaku.65.2-4_138
Limitations and Safety
Limitations: Observational correlation, subgroup-specific result, no administered H2 intervention, and inability to establish direction of causation.
Safety: No hydrogen intervention was administered, so treatment safety was not evaluated.
Original Study and H2HUBB Research Context
This publication is an exact-identity member of H2HUBB Gold v1.1.4. The materialized summary is bounded to the certified source evidence used for this import. Source basis: J-STAGE/CiNii exact English abstract. Original/source record.