[Role of hydrogen gas in regulating of poly (ADP-ribose) polymerase-1 dependent cell death in rat Schwann cells].
Yang Yu, Yang Jiao, Bo Li, Xiaoye Ma, Tao Yang, Keliang Xie, Yonghao Yu · Zhonghua wei zhong bing ji jiu yi xue · 2016
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
In rats, the cytotoxicity, the levels of ONOO(-) and 8-OHdG, and PAR expression in HG+H₂ group were significantly lower than those of the HG group (all P < 0.01). There were no significant differences in above parameters between H₂ group as well as M group and C group. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen affected the outcomes measured in rats. The cytotoxicity, the levels of ONOO(-) and 8-OHdG, and PAR expression in HG+H₂ group were significantly lower than those of the HG group (all P < 0.01).
What the Researchers Studied
The researchers studied rats. The study used a preclinical animal experiment. The comparison condition was control condition or baseline measurements.
What Effects Did Molecular Hydrogen Have?
Reported treatment duration: 48 hours. The cytotoxicity, the levels of ONOO(-) and 8-OHdG, and PAR expression in HG+H₂ group were significantly lower than those of the HG group (all P < 0.01). The authors concluded that high glucose levels could enhance DNA damage that enhance PARthanatos in primary rat Schwann cells. To investigate the protective effects and underlying molecular mechanisms of hydrogen (H₂) on high glucose-induced poly (ADP-ribose) polymerase-1 (PARP-1) dependent cell death (PARthanatos) in primary rat Schwann cells.
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The research population or model was rats. The study used a preclinical animal experiment. The reported treatment duration was 48 hours.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.