Subcutaneous injection of hydrogen gas is a novel effective treatment for type 2 diabetes.
Xiaolong Zhang, Jiaming Liu, Keke Jin, Haifeng Xu, Chuang Wang, Zhuang Zhang, Mimi Kong, Zhengzheng Zhang, Qingyi Wang, Fangyan Wang · Journal of diabetes investigation · 2018
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Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
Glucose tolerance and insulin sensitivity were both improved in H₂ -treated mice. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
The study examined mice.
How Molecular Hydrogen Was Used
H₂ was injected subcutaneously at a dose of 1 mL/mouse/week for 4 weeks.
What the Researchers Found
The bodyweight of H₂ -treated mice did not change over the course of the experiment. Glucose tolerance and insulin sensitivity were both improved in H₂ -treated mice. Diabetic nephropathy analysis showed significant reductions in urine volume, urinary total protein and β2-microglobulin, kidney/bodyweight ratio, and kidney fibrosis associated with subcutaneous injection of H₂.
H₂ Mechanisms / Biological Findings
The source material reviewed did not establish a specific molecular hydrogen mechanism for the reported findings.
Authors’ Conclusion
A distinct authors’ conclusion was not available in the source material reviewed by H2HUBB.